Author's response to reviews Title: A robustness study of parametric and non-parametric tests in Model-Based Multifactor Dimensionality Reduction for epistasis detection Authors:
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Some quality characteristics are well defined when treated as response variables and are related to some independent variables. This relationship is called a profile. Parametric models, such as linear models, may be used to model profiles. However, in practical applications due to the complexity of many processes it is not usually possible to model a process using parametric models.In these cas...
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A survey about methods dedicated to epistasis detection
During the past decade, findings of genome-wide association studies (GWAS) improved our knowledge and understanding of disease genetics. To date, thousands of SNPs have been associated with diseases and other complex traits. Statistical analysis typically looks for association between a phenotype and a SNP taken individually via single-locus tests. However, geneticists admit this is an oversimp...
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تاریخ انتشار 2013